Surface charge distribution: a key parameter for understanding protein behavior in chromatographic processes
نویسندگان
چکیده
Multi-component adsorption of proteins still requires a better understanding local phenomena to improve the development predictive models. In this work, all-atom Molecular Dynamics (MD) simulations were used investigate influence protein charge distribution on capacity. The simultaneous ?-chymotrypsin and lysozyme cation exchanger, SP Sepharose FF, was studied through MD compared macroscopic isotherm experiments. It appears that is relevant information understand specific phenomena, such as multilayer caused by particular electrostatic profile ?-chymotrypsin. Therefore, seem be an interesting way visualize highlight these behaviors.
منابع مشابه
a framework for identifying and prioritizing factors affecting customers’ online shopping behavior in iran
the purpose of this study is identifying effective factors which make customers shop online in iran and investigating the importance of discovered factors in online customers’ decision. in the identifying phase, to discover the factors affecting online shopping behavior of customers in iran, the derived reference model summarizing antecedents of online shopping proposed by change et al. was us...
15 صفحه اولSurface charge: a key determinant of protein localization and function.
Electrostatic charge at the membrane surface has emerged as a crucial determinant of the localization and activation of many proteins containing polycationic domains in their amino acid sequence. The spatiotemporal regulation of surface charge, as well as the downstream effects of dysregulation of surface charge, may have a significant impact on many of the signaling molecules important to canc...
متن کاملStudying Dynamic behavior of Distributed Parameter Processes Behavior Based on Dominant Gain Concept and it’s Use in Controlling these Processes
In this paper, distributed parameter process systems behavior is studied in frequency domain. Based on the dominant gain concept that is developed for such studies, a method is presented to control distributed parameter process systems. By using dominant gain concept, the location of open loop zeros, resulted from the time delay parameter in the process model, were changed from the right half p...
متن کاملA Five-Parameter Yield Surface
This paper is on the elasto-plastic analysis of plane stress problems. A five-parameter yield surface is presented. This yield criterion uses associate flow along with mixed hardening rule. The analytical formulations are written and related computer program for non-linear analysis is prepared. Finally, based on the formulations, numerical examples are solved.
متن کاملA Five-Parameter Yield Surface
This paper is on the elasto-plastic analysis of plane stress problems. A five-parameter yield surface is presented. This yield criterion uses associate flow along with mixed hardening rule. The analytical formulations are written and related computer program for non-linear analysis is prepared. Finally, based on the formulations, numerical examples are solved.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chromatography A
سال: 2021
ISSN: ['1873-3778', '0021-9673']
DOI: https://doi.org/10.1016/j.chroma.2021.462151